Sesamol

Sesamol phofo Boitsebiso ba Base

lebitso	Sesamol phofo
Tlhokomelo	Pula e tšoeu
Cas	533-31-3
Assay	≥99%
Solubility	nsoluble ka metsing kapa joala, e qhibilihang ka har'a Acetic acid, ethyl ester.
Boima ba Molar	138.12 g / mol
Melt Point	62 ho 65 ° C (144 ho 149 ° F; 335 ho 338 K)
Molecular Formula	C7H6O3
Sebaka se belang	21 ho isa ho 127 ° C (250 ho isa ho 261 ° F; 394 ho 400 K) ka 5
SMILES	mmHgO1c2ccc (O) cc2OC1

 

Ke eng Sesamol?

Sesamol ke ntho ea tlhaho ea phenol e fumanoang ka oli ea sesame e sebelisitsoeng le peo ea sesame e halikiloeng. Sesamol (CAS 533-31-3) e nkuoa e le karolo ea mantlha ea oli ea sesame e sebetsang liphellong tsa eona tsa kalafo.

sesame, (sesamum indicum) ke oli ea bohlokoa ea lelapa la Pedaliaceae. E nkuoa e le sejo se seng sa khale sa oli se tsejoang le ho sebelisoa ke motho eseng feela ka boleng ba eona ba phepo empa le ka boleng ba sona ba bongaka. Likarolo tse kholo tsa sesame tse fanang ka boleng ba kalafo ke makhasi le oli ea peo.

Sesamol 533-31-3 kompone e fumaneha ka bongata ntle le metsoako e meng ea lignin ea oli ea sesame, sesamin le sesamolin. Motsoako ona o qhibilihang metsing o nkoa e le antioxidant e matla.

 

Sesamol wo joangrk?

Sesamol e sebetsa ka mekhoa e fapaneng ho fana ka melemo ea eona e mengata ea kalafo joalo ka ts'ireletso ea meriana, litlamorao tsa antioxidant, anti-inflammatory, anti-tumor, anti-radiation le litlamorao tse matla tsa ho senya.

Ka tlase ke mekhoa e meng eo sesamol e sebetsang ho fihlela litlamorao tse boletsoeng;

 

I. E thibela tšenyo ea DNA ka khatello ea mali

Sesamol e ka thibela tšenyo ea DNA ka khatello ea maikutlo e bakoang ke radiation. Mahlaseli a kotsi a baka tšenyo ho lisele tsa DNA ka ho hlohlelletsa ho fetoha ha chromosomal le micronuclei lisele tse ntseng li eketseha.

 

II. E tsosa tšebetso ea li-antioxidants tsa bohlokoa

Sesamol ea sebetsa ka ho laola mesebetsi ea li-enzyme tsa bohlokoa tsa antioxidant tse kang catalase (CAT), superoxide dismutase (SOD), le glutathione peroxidase (GPx), e tsamaeang le maemo a eketsehang a glutathione (GSH). Li-enzyme tsena li bapala karolo ea bohlokoa ho thibela tšenyo ea lisele ke li-radicals.

 

III. E thibela liprotheine tsa pro-apoptotic ka hona e ntlafatsa ts'ebetso ea sele

Liprotheine tsa pro-apoptotic ke liprotheine tse khothalletsang lefu la sele. Li kenyelletsa p53, caspase-3, PARP, le li-enzyme tse mpe. Li-enzyme tsena li kenella lefung le hlophisitsoeng la lisele kahoo li ka fokotsa ts'ebetso ea sele.

Sesamol e bonts'itsoe hore e khothaletsa ts'ebetso ea sele ka ho thibela ts'ebetso ea li-enzyme tsa pro-apoptotic.

 

IV. Ho thibela lipidroxidid tse nang le lipid

Lipid peroxidation ke mofuta oa ho senyeha ha lipid ho hlahang ka lebaka la oxidation. Sena se fella ka ho theoa ha aldehydes e sebetsang, e kang malondialdehyde (MDA) le 4-hydroxynonenal (HNE) e bakang tšenyo ea lisele. Sesamol e bonts'itsoe hore e thibela lipid peroxation ka hona e fana ka ts'ireletso liseleng.

 

V. E thibela ho hlahisoa ha radical mahala ho kenyelletsa le hydroxyl radicals

Li-radicals tsa mahala ke metsoako e sa tsitsang e amanang le maloetse le botsofali. Hydroxyl radicals ke li-oxidants tse matla ka ho fetisisa tse bakang ho kula.

Sesamol e fokotsa tlhahiso ea li-radicals tsa mahala ho kenyelletsa hydroxyl, α, α-diphenyl-β-picrylhydrazyl (DPPH), le ABTS (2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) e matla.

 

VI. E ntlafatsa ts'ebetso e matla ea ho senya

Ntle le ho thibela tlhahiso ea li-radicals tsa mahala, sesamol e khona ho felisa li-radical tse sa lefelloeng joalo ka hydroxyl, lipid peroxyl le tryptophanyl radicals.

 

VII. Ho hatella lisele tsa ho ruruha

Sesamol e thibela litsela tsa ho bonts'a lihlahisoa tse amanang le tlhahiso ea mefuta e sa sebetseng ka hona e fokotsa karabelo ea ts'oaetso.

 

VIII. E fokotsa ho ruruha ha cytokines (TNFcy, IL-1β, le IL-6)

Nitric oxide, e hlahisoang ke iNOS, e lebisa ho ruruheng ha matšoafo ka ho hlohlelletsa li-cytokine tsa ho ruruha, joalo ka TNFcy, le ho matlafatsa karabelo ea ho ruruha. Sesamol e na le bokhoni ba ho thibela ho lokolloa ha TNFcy le IL-1β.

 

IX. Ho ts'oaroa hoa kholo ea sele ka mekhahlelo e fapaneng

Sesamol e bonts'itsoe hore e hlohlelletsa kholo ea lisele ho ts'oaroa ka mekhahlelo e fapaneng ea kholo ea lisele ho kenyelletsa karolo ea S le G0 / G1. Mefuta e thibelang mofets'e ea Sesamol ka hona e thusa, mohlala, ho fokotsa kholo ea lisele tsa mofetše.

 

X. Ts'ebetso ea tsela ea caspase

Li-caspase ke li-enzyme tse amehang lefung la lisele tse hlophisitsoeng. Sesamol e bonts'itsoe hore e kenya tšebetsong litsela tsena ka hona e lebisang lefung la mofetše oa lisele.

 

XI. E hlohlelletsa apoptosis ka tsela ea tlhaho le e ka ntle

Apoptosis ke ts'ebetso ea mmele eo lefu la sele le hlophisitsoeng le hlahang. Ke ts'ebetso ea bohlokoa kaha e thusa 'mele ho felisa lisele tse shoeleng.

Sesamol e kenya apoptosis ka litsela tse peli tse fapaneng, tse ka hare le tse kantle.

 

XII. Thibela autophagy ea mitochondrial

Mitochondrial autophagy ke mofuta o itseng oa ho senyeha ho thusang ho felisa mitochondria e senyehileng.

Ha sesamol e thibela ts'ebetso ena, ebe apoptosis ea hlohlelletsoa.

 

XIII. E fokotsa maemo a nitrite le neutrophil

Li-nitrite le li-neutrophil li nka karolo karabong ea ho ruruha. Li kentse letsoho ho lokolloeng ha nitric oxide e lumellanang le karabelo ea ho ruruha ka ho fokotsa kapa ho thibela ho ruruha.

Sesamol e bapala karolo e le anti-inflammatory agent ka ho fokotsa maemo a nitrites le neutrophils.

 

Ke eng sesamol e sebelisetsoang?

Sesamol e sebelisetsoa melemo e fapaneng ea bophelo bo botle ho kenyelletsa;

 

i. Khatello ea mali e phahameng.

Oli ea Sesame e sebelisoa hammoho le lithethefatsi tse 'maloa tsa khatello ea mali e le meriana e netefalitsoeng ea ho theola khatello ea mali.

Phuputso e batsi ka oli ea sesame e fana ka maikutlo a hore sesamol le sesamin (lignans tse fumanehang ka oli ea sesame) li bapala karolo e kholo ho laoleng khatello ea mali. Ho nka oli ea sesame, haholo ho pheha ka eona, bakeng sa libeke tse tharo ho theola khatello ea mali ho batho ba nang le khatello ea mali e tloaelehileng.

Nakong ea lipatlisiso, lingaka li ile tsa beha sehlopha sa bakuli ba nang le khatello ea meriana meriana (Procardia, Nefedica le Adelta) nako ea matsatsi a 21. Le ha khatello ea mali e ne e fokotsehile hanyane, e ne e sa tloaeleha. Oli ea Sesame e ne e sebelisoa e le sebaka sa meriana, mme bakuli ba ile ba lekoa kamora nako e tšoanang. Phello e bile hore khatello ea mali ea bona e ne e theohetse setloaeling.

Lingaka li ile tsa pheha khang ea hore sephetho se tlatselitsoe haholo ke boholo ba sesamol le sesamin ka oli ea sesame e phehiloeng. Haeba ho ka fumanoa hore ho kenyelletsa oli ea sesame lijong tsa batho ba nang le khatello e phahameng ea mali ho ka sebetsa hantle ho feta ho ba fa meriana.

Liphetho tsena li tlalehiloe ho American Heart Association nakong ea kopano ea selemo le selemo ea Inter-American Society of Hypertension ke Moprofesa Devarajan Sankar oa Univesithi ea Annamalai, India.

 

ii. Thibelo ka maleng.

Lipatlisiso ka litlamorao tsa sesamol ka ho koala mala li bontša hore e ka ba betere haholo ho feta aspirin. Phuputsong e mabapi le ulcerative colitis, IBD (mafu a ho ruruha a mala), e bakang tšenyo ea lisele tsa mucosal ka ho senya tsamaiso ea ho ruruha. Phuputsong e amanang le likhoto, sesamol e fumanoe e fokotsa mesebetsi ea li-enzyme tse bakang ho ruruha.

Le ha aspirin e tsejoa ka mokhoa o atlehileng ho bolaea mathata a ho ruruha ha e nooa, e ka lebisa ho nts'etsopele ea liso ka ts'ebeliso ea nako e telele. Aspirin e baka likotsi tsa "gastroduedonal" ka ho senya lisele.

Liphuputso tse ling li bontša hore nasogastric intubation ea sesamol ho bakuli ba nang le lithibelo tse nyane tsa mala hammoho le tlhokomelo e tloaelehileng e theola menyetla ea ho etsoa opereishene.

 

iii. Lefu la pelo.

Mabaka a kotsi a bakoang ke mafu a pelo le methapo a na le karolo e kholo ho shoa hoa lefats'e le ho kula. Li ka lebisa khatellong ea oxidative mme haeba ho sa alafatsoe ho mpefala ho isa keketsehong ea tlhahiso ea mefuta ea oksijene e sebetsang, ho kenyeletsoa sistimi e sothehileng ea antioxidant

Sesamol e sebelisa matla a eona a anti-oxidative ho thibela mafu a atherosclectoric a pelo le likotsi tse kang hypercholesterolemia, hypertriglyceridemia, khatello e phahameng ea lipoprotein cholesterol le lipoprotein tse nang le bongata bo tlase.

Liphuputso tse ling li fihletse qeto ea hore sesamol e na le litlamorao tse matlafatsang tsa lera le lipid. Ho feta moo, e fana ka ts'ireletso ho myocardium khahlano le lefu la pelo le bakoang ke DOX.

 

IV. Khōlo ea bana.

Sesamol e sebelisoa maemong a fapaneng a kholo ea kholo ea bana. Liphuputsong tse fapaneng, sesamol e sebelisetsoang ho fokotsa ADHD ho bana ba nang le mathata a kelello e ne e bitsoa e sebetsa hanyane haeba e sebelisoa ka bongata. Ho haella ha DHA ho atile haholo ho bana ba nang le ADHD.

Liphuputso tse fetang leshome li bonts'a melemo e metle matšoao a ADHA ho kenyeletsoa ho bala mantsoe, ho se tsotelle, ho ithuta ka pono, mohopolo o sebetsang le ho se tsotelle.

Masea a sililitsoeng ka oli ea sesame libeke tse 'ne a tlaleha kholo e ntlafalitsoeng le ho ba mafolofolo' meleng.

 

v. Lefu la tsoekere.

Sesamol e sebetsa ka katleho e le tlatsetso ea meriana ea lefu la tsoekere ho theola maemo a tsoekere maling kapele. Ho nka lisebelisoa tsa sesamol kapa ho fapana le ho fetohela phepong ea oli ea sesame ha o le lithethefatsi tsa lefu la tsoekere ho fana ka chai e ngata bakeng sa mosebetsi.

Lipatlisisong tse 'maloa, boholo ba bakuli ba lefu la tsoekere la mofuta oa 2, sesamol e bonts'itse sephetho se setle. E 'ngoe ea lithuto e ne e ama lihlopha tse tharo, se seng le se seng se tšoeroe ke lefu la tsoekere la mofuta oa 2. Sehlopha se seng se ne se fuoa sesamol se le seng, se seng se fuoa litlhare tsa letsatsi le letsatsi tsa glibenclamide (Glyburide), 'me sa ho qetela se fuoa lisamol le Glyburide nako e ka etsang libeke tse 7.

Sesamol ho tlalehiloe hore e na le phello ea synergetic le glyburide, kaha kalafo e kopaneng e theotse hemoglobin A1c le maemo a tsoekere ea mali haholo, ebile e betere ho feta efe kapa efe ea kalafo e le 'ngoe.

Hyperlipidemia. Bafuputsi ba tlaleha hore sesamol e sebelisetsoang ho chesa k'holeseterole le lipids tse ling maling e fane ka litholoana tse ntle. Tekong ea mohlala, ts'ebetso ea sesamol e ile ea lekoa holima hyperlipidemia e bakoang ke ho ja lijo tse ngata, hyperlipidemia e sa foleng, hypercholesterolemia le hyperlipidemia e matla.

Ho fokotseha ha maemo a triacylglycerol ha liphetho li bontša hore sesamol e fokotsa monya oa triacylglycerol haholo. Sesamol e boetse e sebelisetsoa ho khutlisa maemo a phahameng a k'holeseterole.

Liphuputso li fana ka maikutlo a hore sesamol supplement e eketsa ho tsoa ha k'holeseterole hammoho le ho fokotsa ho monya ha eona.

 

VI. Metabolic syndrome le botenya.

Sesamol ho tlalehoa hore e na le bokhoni bo fapaneng ba bioloji ho kenyelletsa le bokhoni ba ho khutlisa botenya le mathata a ts'oaetso. Ho tlalehoa hore e kanna ea thibela litlamorao tse khahlano le botenya.

Phuputso e entsoeng ho leka hore na sesamol e sebetsa joang ho nona, ho fumanoe hore e ka laola metabolism ea lipid metabolism. Sena se ile sa ntlafatsa ho hanyetsa insulin le ho eketsa tahlehelo ea boima ba 'mele. Botenya le mathata a eona a amanang le ts'oaetso a amana haholo le ho bokellana ha lipid ka har'a 'mele. Ho fokotseha ha pokello ho bolela mokhoa o fetotsoeng oa botenya.

Sesamol tšebeliso e eketsa lipolysis, mafura a asiti oxidation le phokotso ea lipogenesis ea hepatic, lintlha tsa bohlokoa ho theoleng ho bokellana ha lipid. Mesebetsi ena (ke hore, ho nka lipid, synthesis le catabolism) ke tse ling tsa tse etsahalang sebeteng.

Batho ba sebelisang sesamol ba tlalehile lifaele tse ntlafalitsoeng tsa hepatic le serum lipids, hape ba ntlafalitse kutlo ea insulin.

 

VII. Ramatiki ea ramatiki, Osteoarthritis le lefu la masapo.

Le ha ramatiki ea lefu la masapo, lefu le bohloko le le sa foleng la ho itšireletsa mafung, le na le liphekolo tse 'maloa tsa lik'hemik'hale, ts'ebeliso ea tsona ea nako e telele hangata ke hepatotoxic. Sesamol e ka ba pheko ea tlhaho e ka bang teng. Liphuputso tse etsa lipatlisiso tse tšoanang li tlalehile hore sesamol e na le litlamorao tse ntle tsa anti-arthritic le anti-inflammatory tse ntlafalitseng litlamorao tsa ramatiki ea ramatiki.

Osteoarthritis ke sesosa se seholo sa bohloko ba manonyeletso, bo hakantsoeng hore bo ka ama karolo ea 15 lekholong ea baahi ba lefatše. Ho imeloa kelellong, leha ho le joalo, ho na le karolo e kholo ho se sebetse ha mesifa. Lipatlisiso ka litlamorao tsa sesamol ho bohloko ba manonyeletso bo amanang le lefu la masapo a mabeli li bontšitse hore ho nka sesamol tlatsetso bakeng sa beke ho ka theola bohloko. Sena se bakoa ke thepa ea sesamol e khahlanong le oxidative.

Bo-rasaense ba fihletse qeto ea hore ts'ebetso e ts'oanang le postmenopausal osteoporosis e ntse e tsoela pele ho baka ovariectomy, moo ho nang le tahlehelo e tsoelang pele ea boima ba masapo le matla. Ka hona ho fumanoa hore ho senyeha ha masapo ho bakoa haholo ke estrogen. Sesamol ho tlalehoa hore e tlama li-receptor tsa estrogen le ho etsa sengoloa sa liphatsa tsa lefutso tsa estrogen. Liphetho tse ntle li khothaletsa matla a masapo ka ho hlahisa liprotheine tsa masapo.

 

Viii. Lefu la Alzheimer, matšoenyeho le stroke.

Lefu la Alzheimer ke ho holofala ha boko ho tsoelang pele ho bakoang ke ho senyeha ha lisele tsa boko. Hangata e felisa boikemelo ba kelello ba batho ba amehileng. Litla-morao tsa sesamol li tlalehiloe li ts'episa. Phuputso e ne e etselitsoe ho hlakisa bokhoni ba kalafo ea sesamol ho lefu la sethoathoa, boemo bo amanang haholo le ho holofala ha kelello le khatello ea mali. Phuputso e phethile ka hore sesamol e na le litlamorao tse khahlisang khahlanong le stroke, ho holofala ha kelello, ho oela le khatello ea mali. Sesamol ts'ebeliso ea meriana ea antiepileptic e ka ba molemo.

 

Melemo ea Sesamol

[a]. Sesamol Anti-oxidant liphello

Ho imeloa kelellong ho bakoang ke ho se leka-lekane ha tlhahiso ea li-radicals mahala le li-antioxidants 'meleng. Hangata hona ho lebisa tšenyo ea sele le khatello ea mali e nkuoang e le sesosa sa mathata a mangata.

Ho imeloa kelellong ke mokhoa oa tlhaho oa 'mele o lebisang botsofaling.

Antioxidants ka lehlakoreng le leng ke lintho tse thibelang tšenyo ea lisele ka lebaka la radicals ea mahala. Hangata li bitsoa mahala radicals scavengers.

Sesamol ke motsoako o matla le o matla oa antioxidant oa oli ea sesame. E sebetsa ka mekhoa e fapaneng ho fana ka litlamorao tsa antioxidant. Mekhoa ena ea ts'ebetso e kenyelletsa tlhabollo ea mesebetsi ea bohlokoa ea antioxidant, ts'ireletso ea DNA ts'enyo ea radiation, ho senya radicals ea mahala, ho thibela lipid peroxation le ts'ireletso ho radiation ea ultraviolet.

Phuputso e lekolang ts'ebetso ea radioprotective ea sesamol khahlano le gamma irradiation ho DNA. Tšenyo ea DNA e bakoa ke ho hlahisa likheo tse le 'ngoe kapa tse habeli ka moloko oa mefuta ea oksijene e sebetsang.

Sesamol e fumanoe e thibela likheo tsa DNA tse le 'ngoe. E boetse e fokotsa maemo a li-radicals tsa mahala haholo-holo li-hydroxyl, DPPH le ABTS radicals, tseo kaofela li neng li hokahane le likhefutso tse se nang moeli kapa tse habeli.

 

[b]. Sesamol Anti-inflammatory melemo e

Ho ruruha ke ts'ebetso ea 'mele eo' mele oe sebelisang ho loants'a mahlahana a kantle ho naha joalo ka libaktheria, li-fungus kapa kotsi. Leha ho le joalo, ho ruruha ho sa foleng ho kotsi 'meleng kaha ho lebisa ho mathata a fapaneng.

Lisebelisoa tse khahlanong le ho ruruha li thusa ho sireletsa 'mele tšenyo ka ho loantša ho ruruha. Sesamol e sebetsa ka mekhoa e fapaneng ho fana ka litlamorao tse khahlano le ho ruruha. Mekhoa ena ea ts'ebetso e kenyelletsa ho thibela lisele tsa ho ruruha, ho fokotsa tlhahiso ea nitrites le ho hatella tšebetso le litsela tsa ho ruruha.

Phuputsong ea likhoto tse nang le lipopolysaccharide LPS e bakoang ke kotsi ea matšoafo, sesamol e fumanoe e hatella li-cytokines tse khahlanong le ho ruruha hape e sitisitse tlhahiso ea nitric oxide le prostaglandin E2 (PGE2). Sesamol le eona e fumanoe e phahamisa ts'ebetso ea adenosine monophosphate-activated protein kinase (AMPK). Sena se thusa ho thibela ho ruruha hape ho fokotsa tšenyo ea sele.

[c]. Kankere ea Sesamol liphello

Sesamol e na le thepa e thusang ho loants'a lisele tsa mofets'e ho kenyelletsa ts'ebetso e khahlanong le ho ata ka mekhoa e fapaneng joalo ka ho thibela bokhoni ba lera, ho ts'oara kholo ea sele ka mekhahlelo e fapaneng le ho baka apoptosis.

Phuputsong e kenyelletsang mohala oa sele ea mofetše oa kolone ea DLD-1, sesamol e sebelisitsoe ka tekanyo ea 12.5-100 μM. Ho fumanoe hore ts'ebetso ea COX-2 ea sengoloa e fokotsehile ka 50%.

Phuputsong e ngoe, sesamol e sebelisitsoeng ka litekanyetso tse phahameng tsa 0.5-10 mM e fumanoe e baka apoptosis ho HCT116 ka ho eketsa oksijene e sebetsang ea oksijene (O2 • -) ka mokhoa o itšetlehileng ka tekanyetso. Sena se lebisitse ts'ebetsong ea tsela ea ho saena ea JNK e khothalletsang tšenyo ea mitochondrial. Sena le sona se fella ka ho lokolloa ha cytochrome c e qetellang e kenya tšebetsong caspase ka hona e hohelang apoptosis.

 

[d]. Seasomol -Ba khahlanong le mutagenic liphello

Mutagenicity e bolela bokhoni ba moemeli (mutagen) ho baka liphetoho. Phetoho eo e leng phetoho liphatseng tsa lefutso e ka lebisa tšenyo ea lisele mme ho nahanoa hore e baka mafu a mang a kang mofets'e.

Sesamol e bonts'itsoe hore e na le thepa e matla ea anti-mutagenic. Melemo ea eona e khahlanong le mutagenic e hlahisoa ke tšebetso ea antioxidant mme haholoholo ke bokhoni ba ho hlasela li-radicals tsa mahala.

Phuputsong, mutagenicity e hlohlellelitsoe ke ho hlahisa li-radicals tsa oksijene ke tert-butylhydroperoxide (t-BOOH) kapa hydrogen peroxide (H2O2). Sesamol e fumanoe e hlahisa litlamorao tse matla tsa anti-mutagenic mefuteng ea liteko tsa Ames TA100 le TA102. Mofuta oa TA102 o tsejoa o le bohlokoa haholo ho mefuta ea oksijene e sebetsang. Sesamol e boetse e bontšitsoe e thibela mutagenicity ea sodium azide (Na-azide) mofuteng oa liteko oa TA100.

 

[e]. Sesamol Protection ho tloha mahlaseling

Mahlaseli a kotsi a bolela matla a tsamaeang ka sebopeho sa maqhubu kapa likaroloana. Mahlaseli a kotsi a ka etsahala haholo tikolohong ea rona. Leha ho le joalo, mahlaseli a kotsi a ka ba kotsi haeba a sa laoloe. Ho pepesetsoa mahlaseli a nakoana ho ka lebisa ho mafu a hlobaetsang joalo ka ho kula ha radiation le ho chesoa ke letsatsi.

Ho pepesehela mahlaseli a kotsi ho baka mathata a tebileng ho kenyelletsa mofetše le lefu la pelo.

Phuputsong ea litoeba tse nang le tšenyo ea DNA e bakoang ke mahlaseli a kotsi, sesamol e ile ea hlahlojoa bakeng sa tšireletso ea eona khahlanong le radiation. Ho phekoloa pele ha litoeba ka sesamol ho felletse ka ts'ireletso khahlano le tšenyo ea DNA e bakoang ke radiation.

 

[f]. Tšireletso ea pelo

Sesamol ho tlalehiloe hore e fana ka tšireletso ho pelo ho tsoa likotsi.

Phuputsong ea ho lekola matla a ts'ireletso ea sesamol khahlano le kotsi ea myocardial, sesamol prereatment e ile ea etsoa ho (50 mg / kg) e entsoe matsatsi a 7 pele ho nako ea ho buuoa.

Phuputso ena e fumane hore sesamol e fokolitse boholo ba infarct haholo, e sebelisitse matšoao a pelo, e thibela lipid peroxidation, ho kenella ka neutrophil hammoho le ho phahamisa li-antioxidants. Ho tlalehiloe hore sesamol phofo e lebisa ho fokotseheng ha liphatsa tsa lefutso tse haelloang, Caspase-3 apoptotic protein , hape e ntlafalitse tšebetso ea protheine ea anti-apoptotic Bcl-2.

 

[g]. Sesamol Li-radicals tsa mahala li senya

Li-radicals tsa mahala ke liathomo tse sa tsitsang tse fumanang lielektrone habonolo ho liathomo tse ling. Ka bobeli li molemo ebile li chefo ho latela mohopolo oa tsona. Maemong a tlase li-radicals tsa mahala li bapala karolo ea boits'oaro ba mmele, leha ho le joalo, ha mohopolo oa bona o le holimo haholo li ba kotsi. Li-radicals tsa mahala li hlahisa khatello ea mali e ka senyang lisele mme e ka baka mathata a sa foleng le a fokolang a kang mofetše, mafu a pelo, ramatiki, lera la mahlo le mafu a methapo ea pelo.

'Mele ea rona e loants'a litlamorao tsa khatello ea mali ka ho hlahisa li-antioxidants leha ho le joalo e kanna ea se lekane mme e hloka tlatsetso ka lijo kapa li-supplement.

Sesamol e na le bokhoni ba ho thibela sebopeho sa li-radicals tsa mahala le ho ts'oants'a maqhubu a mahala.

Phuputsong e kenyelletsang lisele tsa batho ba baholo tsa letlalo la motho ea letlalo (HDFa) tse pepeselitsoeng UVB, sesamol prereatment e ile ea hlahlojoa khahlano le cytotoxicity, li-intracellular reactive oxygen species (ROS), lipid peroxidation, antioxidant status, le oxidative DNA tshenyo. Sesamol e fumanoe e fokotsa haholo lipid peroxidation, cytotoxicity, ROS e kahare, le tšenyo ea DNA ea lisele tsa letlalo la motho. Sena se hlahisitsoe ke bokhoni ba tlatsetso ea sesamol ho lata ROS.

Phuputso e ts'oanang e tlalehile ts'ebetso e eketsehileng ea enzymatic le e seng enzymatic e tlatsetsang ho ts'ebetso e ntle ea antioxidant.

 

[h]. E theola k'holeseterole e maling

Cholesterol ea mali ke ntho e kang mafura 'meleng oa hau. E hlokahala ke 'mele ho aha lisele tse phetseng hantle empa ka bongata bo nepahetseng. Cholesterol e tsamaisoa ka mefuta e 'meli ea lipoprotein, low-density le high-density. Ka hona e tlisa mefuta e 'meli ea k'holeseterole, k'holeseterole e tlaase ea lipoprotein (LDL) le k'holeseterole e phahameng ea lipoprotein (HDL).

Hangata LDL e bitsoa cholesterol e mpe ho tloha maemong a phahameng a LDL eketsa kotsi ea ts'oaetso ea methapo ea mali le mafu a mang.

Sesamol e ka fokotsa boemo ba k'holeseterole hammoho le boemo ba triacylglycerol 'meleng.

Tekong ea mamello ea mafura, sesamol (100 le 200 mg / kg) e fumanoe e le ntle haholo (P <0.05) e fokotsa ho monya ha triacylglycerol ka hona e theola boemo ba triacylglycerol 'meleng. Triacylglycerol ke karolo e ka sehloohong ea mafura a bolokiloeng ka har'a lisele tsa adipose.

Phuputsong ea litoeba tsa Switzerland tsa albino tse nang le hyperlipidemia, sesamol supplement ho 50 le 100 mg / kg e tlalehiloe e fokotsa maemo a k'holeseterole le triacylglycerol haholo.

Mosebetsi oa sesamol o fokotsang li-cholesterol le li-triacylglycerol o bakoa ke bokhoni ba ona ba ho fokotsa ho monya le ho eketsa ho tsoa hoa k'holeseterole.

 

[i]. Sesamol e ruisa letlalo molemo

Letlalo la motho ke karolo ea bohlokoa ea li-integumentary system eo mosebetsi oa eona oa mantlha e leng ho fana ka ts'ireletso ho litho tsa 'mele.

Sesamol e tsoela letlalo molemo ka litsela tse fapaneng ka lebaka la thepa ea lona e matla e kenyeletsang antioxidant, le anti-inflammatory activity. Sesamol e ruisa letlalo molemo ka

 

· Ho sireletsa letlalo mahlaseling a ultraviolet (UV)

Ho pepesehela khanya ea letsatsi nako e telele ho ka lebisa molokong o phahameng o sa tloaelehang oa mefuta ea oksijene e sebetsang (ROS), e ka bakang tšenyo ea letlalo joalo ka ho senyeha ha collagen ka hara dermis le hyperplasia ea epidermis.

Sesamol e khona ho nyolla li-radicals tse sa lefelloeng tse hlahang ka lebaka la ho pepeseha nako e telele letsatsing kahoo e sireletsa letlalo ho senyeha ha mahlaseli a DNA. E fana ka seaparo se sireletsang se thusang ho thibela letlalo ho senyeha ke mahlaseli a UV.

Liphuputso li tlaleha hore sesamol e ka fokotsa cytotoxicity e bakiloeng ke UVB. Ho tlalehoa hape hore e thibela melanin biosynthesis ka ho theola polelo ea tyrosinase, MITF, TRP-1, TRP-2, le MC1R liseleng tsa melan-a.

Phuputso e 'ngoe e fumane hore sesamol le eona e ka sitisa melanin synthesis ka ho susumetsa cAMP / protein kinase A (cAMP / PKA), protein kinase B (AKT) / glycogen synthase kinase 3 beta (GSK3β) / CREB, TRP-1, le MITF ho B16F10 lisele

 

· Thusa ho boloka letlalo le khanyang

Sesamol e tsejoa e le antioxidant e matla. E kenella ka hare letlalong ka tsela eo e fepa letlalo. Sena le sona se thusa ho fumana letlalo le khanyang.

 

· E felisa makhopho

Makhopho ke boemo boo masoba a letlalo a koetsoeng ke oli, litšila le likokoana-hloko tse ling tse kotsi.

Sesamol e na le thepa ea likokoana-hloko e e nolofalletsang ho felisa likokoana-hloko kahoo o fumana letlalo ntle le makhopho.

 

· E fana ka litlamorao tse khahlano le botsofali

Botsofali ke mokhoa o itekanetseng le o tsoelang pele oa bophelo. Leha ho le joalo botsofali pele ho nako bo ka hlaha ka lebaka la lintlha tse 'maloa tse kang ho pepesehela mahlaseli a UV halelele, khatello ea mali har'a ba bang.

Sesamol e fana ka tšebetso e matla ea antioxidant e thibelang letlalo le 'mele ho tsoa ho oxidation ea lisele hape e ntlafatsa ntlafatso ea letlalo.

Sesamol le eona e tlalehiloe e thibela ho hlaha ha mela, masoba le masosong.

 

[j]. Melemo ea Sesamol bakeng sa moriri

Ts'ebeliso ea lihlooho tsa oli ea sesame e fepa letlalo la hlooho, moriri oa moriri le li-shafts. Sena se khothaletsa kholo ea moriri o phetseng hantle. E boetse e thusa ho folisa hlooho efe kapa efe e senyehileng ka lik'hemik'hale nakong ea kalafo ea moriri kapa ho daea.

Ho kuta moriri pele ho nako ho ka hlaha ka lebaka la phokotso ea bokhoni ba 'mele ba ho etsa melanin e lekaneng, hammoho le lintlha tse ling tse kang khatello ea mali, phetoho ea bophelo ba liphatsa tsa lefutso ho kenyelletsa le lijo le ts'ebeliso ea lithethefatsi.

Sesamol supplement e ipakile e khona ho boloka 'mala oa moriri hape e fifatsa moriri o seng o le moputsoa.

Ntle ho moo, sesamol e ka thusa ho felisa mokokotlo. Dandruff e ka hlaha ka lebaka la letlalo le omeletseng, ho hanana le lihlahisoa tsa moriri le kholo ea fungus hloohong har'a lintlha tse ling. Sesamol e thusa ho fepa letlalo ka hona ho boloka letlalo la hlooho le phetseng hantle ka hona le thibela ho hlaha ha dandruff. Ts'ebetso ea antibacteria e boetse e netefatsa hore letlalo la hlooho ha le na likokoana-hloko tse bakang matšoafo.

 

Mekhoa e meraro ea maiketsetso ea sesamole

①. Ho qotsetsoa oli ea Sesame

Sesamol Ts'ebetso e tsoang ho oli ea Sesame ke mokhoa o bonolo ka ho fetisisa ho e meraro. Leha ho le joalo, e theko e boima haholo. Kahoo mokhoa ona ha o motle bakeng sa tlhahiso ea indasteri, haholoholo ka lebaka la litšenyehelo tse phahameng tsa tlhahiso.

 

②. Synthetic synthesis e tsoang ho piperamine

Le ha e le hantle moruo bakeng sa tekanyo e kholo ea Sesamol Production, tsela eohle ea syntamol synthesis e tsoang piperamine e sebetsa bakeng sa tlhahiso e nyane ha ts'ebetso ea hydrolysis le hydrolysis e sebelisoa. Boemong bo joalo, mokhoa oa ho kopanya pigment ka lebaka la ho kopanya le ho arabela ka lehlakoreng o ke ke oa qojoa.

 

③. Tsela ea semi-synthetic e tsoang ho jasmonaldehyde

Mokhoa o entsoeng ka maiketsetso o tsoang ho jasmonaldehyde ke ts'ebetso e sebelisoang ka ho fetisisa ea sesame phenol ho ea fihla mererong ea indasteri. Ts'ebetso e kenyelletsa oxidation le hydrolysis mme ka lebaka leo, sesame phenol e hlahisang ke ea boleng bo holimo le e mebala e metle.
Ts'ebetso e sebelisa theknoloji e bolokang chelete e ngata e sebelisang chelete e ngata, e nolofalletsang karohano e potlakileng ea sehlahisoa sebakeng sa ho qhekella. Sena se fokotsa monyetla oa ho hlaha ha lehlakore haholo. Ha ho makatse hore sehlahisoa sa ho qetela (kristale e tšoeu e tšoeu) se boleng bo holimo ho latela mebala le sesamol segokanyipalo.

 

Ho ea hokae reka sesamol

Sesamol phofo e fumaneha marang-rang ho fapana Baetsi ba sesamol. Boholo ba basebelisi ba sesamol ba reka ho fapana websites, tse ling e le tsa ho rekisa kapa ho rekisa ka bongata.

Netefatsa bonnete ba ntho e ngoe le e ngoe moetsi oa sesamol ho sebedisa melao ya naha e hlalositsweng pele o reka.

 

References

1. Joo Yeon Kim, Dong Seong Choi le Mun Yhung Jung "Ketsahalo ea Antiphoto-oxidative ea Sesamol ho Methylene Blue- le Chlorophyll-Sensitized Photo-oxidation ea Oli" J. Agric. Lijo Chem., 51 (11), 3460 -3465, 2003.
2. Kumar, Nitesh & Mudgal, Jayesh & Parihar, Vipan & Nayak, Pawan & Nampurath, Gopalan Kutty & Rao, Chamallamudi. (2013). Phekolo ea Sesamol e fokotsa maemo a Plasma Cholesterol le Triacylglycerol ho Mouse Models of Acute and Chronic Hyperlipidemia. Lipids. 48. 633-638. 10.1007 / s11745-013-3778-2.
3. Majdalawieh, AF, & Mansour, ZR (2019). Sesamol, lignan e kholo ea lipeo tsa sesame (sesamum Symbum): Thepa ea anti-cancer le mekhoa ea ts'ebetso. European Journal of Pharmacology, 855, 75-89.ETSAHALA: 10.1016 / j.ejphar.2019.05.008.
4. Ohsawa, Toshiko. "Sesamol le sesamol e le li-antioxidants." Indasteri e ncha ea Lijo (1991), 33 (6), 1-5.
5. Sesamol Archived 2010-01-14 ho Wayback Machine ho Chemicalland21.com
6. Wynn, James P .; Kendrick, Andrew; Ratledge, Colin. "Sesamol e thibela ho hola le metabolism ea lipid ho Mucor circinelloides ka ts'ebetso ea eona ho enzyme ea malic." Lipids (1997), 32 (6), 605-610.

 

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