Cannabidiol (CBD)

Cannabidiol (CBD) phofo Boitsebiso ba Base

lebitso	Cannabidiol （CBD）
Ponahalo	Ho soeufetse ho ea ho phofo e mosehla ea kristale
Cas	13956-29-1
Assay	≥99% (HPLC)
Solubility	E qhibiliha ka har'a oli, e qhibiliha ka ho fetesisa ka ethanol le methanol, ha e qhele ka metsing
Boima ba 'mele	314.46
Melt Point	62-63 ° C
Molecular Formula	C21H30O2
mohloli o moholo	Indasteri hemp
Storage Temp	Mocheso oa kamore, lula o omme, hole le khanya
Kereiti ya	Meriana ea Meriana

 

ke eng Cannabidiol (CBD)?

Cannabidiol e tsejoa e le CBD e leng e 'ngoe ea metsoako e fetang 100 ea lik'hemik'hale e tsejoang e le li-cannabinoids tse fumanoang semeleng sa cannabis kapa matekoane, Cannabis sativa. E arotsoe 'me e hloekisitsoe ho tsoa litlama tsa Cannabis sativa, e na le likhahla tse nyane haholo tsa THC. Tetrahydrocannabinol (THC) le cannabidiol (CBD) ka bobeli li sebelisana le li-receptor tsa kannete ho pholletsa le 'mele. Ha e bapisoa le 9-THC, CBD ha e na chefo kaha ha e hlahise ts'ebetso ea kelello. E na le li-analgesic, anti-inflammatory, antineoplastic le chemopreventive. Ha tsamaiso e le teng, cannabidiol (CBD) e etsa mesebetsi ea eona e khahlanong le ho ata, anti-angiogenic le pro-apoptotic ka mekhoa e fapaneng, e kanna ea se kenyeletse ho saena ka kamohelo ea li-cannabinoid 1 (CB1), CB2 kapa vanilloid receptor 1. CBD khatello ea kelello ea reticulum (ER) mme e thibela ho saena ha AKT / mTOR, ka ho etsa joalo ho kenya tšebetsong ho itšireletsa kahare le ho khothaletsa apoptosis. Ntle le moo, CBD e ntlafatsa moloko oa mefuta ea oksijene e sebetsang (ROS), e ntlafatsang apoptosis. Moemeli enoa o boetse o phahamisa polelo ea molek'hule ea adhesion 1 (ICAM-1) le inhibitor ea lisele tsa metalloproteinases-1 (TIMP1) mme e fokotsa polelo ea inhibitor ea DNA e tlamang 1 (ID-1). Sena se thibela ho hlaseloa ha lisele tsa mofetše le metastasis. CBD e kanna ea kenya tšebetsong mofuta oa vanilloid oa mofuta oa vanilloid oa nakoana (TRPV2), o ka eketsang ts'ebeliso ea mahlahana a fapaneng a cytotoxic liseleng tsa mofetše. Phello ea analgesic ea CBD e buelloa ka ho tlama moemeli enoa le ho e etsa hore e sebetse CB2. Cannabidiol e sebelisoa haholo bakeng sa lefu la sethoathoa (lefu la sethoathoa) kapa lefu la dravet le phomolo ea matšoao a bohloko bo tebileng ba methapo ea kutlo kapa maemo a mang a bohloko joalo ka mofets'e. FDA e amohetse CBD ka 1, 'me ke eona feela kalafo e lumelletsoeng ea FDA bakeng sa bakuli ba nang le lefu la Lennox-Gastaut le lefu la Dravet.

 

Cboqhetse (CBD) Mehato ea Ketso

Mokhoa o nepahetseng oa ketso ea CBD le THC ha o utloisisoe ka botlalo hajoale. Leha ho le joalo, hoa tsebahala hore CBD e sebetsa ka li-receptor tsa li-cannabinoid (CB) tsa endocannabinoid system, tse fumanehang libakeng tse ngata tsa mmele, ho kenyeletsoa le lits'ebetso tsa methapo ea kutlo le bohareng, ho kenyeletsoa le boko. Sistimi ea endocannabinoid e laola likarolo tse ngata tsa mmele tse kenyeletsang bohloko, mohopolo, takatso ea lijo le maikutlo. Haholo-holo, li-receptor tsa CB1 li ka fumanoa tseleng ea bohloko ea boko le lesapo la mokokotlo moo li ka amang analgesia e bakoang ke CBD le anxiolysis, mme li-receptor tsa CB2 li na le tšusumetso liseleng tsa 'mele tsa ho itšireletsa mafung, moo li ka amang lits'ebetso tse khahlano le ho ruruha tsa CBD . Cannabidiol (CBD) ke metabolism e hlahang sebeteng le mala. Ho tsuba bioavailability ke hoo e ka bang 31%. Bophelo ba halofo ea bophelo ba CBD kamora ho fafatsa oromucosal bo pakeng tsa lihora tsa 1.4 le 10.9, matsatsi a 2 le a 5 kamora tšebeliso e sa foleng ea molomo, le lihora tse 31 kamora ho tsuba. CBD e tla fihlela mohopolo o moholo oa plasma lipakeng tsa hora ea 0 le 4. CBD e bonts'itsoe hore e sebetsa e le "allosteric modulator" e mpe ea "cannabinoid" CB1 receptor, e leng G-Protein Coupled Receptor (GPCR) e ngata ka ho fetesisa 'meleng. Tsamaiso ea Allosteric ea receptor e fihlelleha ka ho feto-fetoha ha tšebetso ea motho ea amohelang sebaka sebakeng se sebetsang se ikhethileng ho tloha sebakeng sa agonist kapa sa mohanyetsi se tlamang. Litholoana tse mpe tsa "allosteric modulatory" tsa CBD li bohlokoa kalafong ea bongaka kaha li-agonists tse tobileng li lekantsoe ke litlamorao tsa bona tsa kelello ha bahanyetsi ba tobileng ba fokotsoa ke litlamorao tsa bona tse nyahamisang.

 

Mokhoa oa ho sebelisa Cboqhetse (CBD)?

Cannabidiol (CBD) ke ntšang hanf e etselitsoeng melemo ea eona ea bophelo bo botle. Litsela tse peli tse tloaelehileng tsa ho li isa 'marakeng ke tsa molomo le lihlooho, joalo ka li-capsules, litlolo, litlolo, le tse ling. Lioli tsa CBD ke mokhoa o tsebahalang haholo oa ts'ebeliso, ke tsela e sebetsang ea ho noa li-cannabinoid. Ho metsa marotholi a 'maloa a oli ea CBD ho sebetsa e le mokhoa o bonolo le o bonolo ho feta oa ho ja molek'hule ka tsela ena. Cannabidiol e KA SIRELETSA HANG ha e nooa ka molomo kapa e fafatsoa ka tlas'a leleme ka nepo. Cannabidiol ka litekanyetso tsa ho fihlela ho 300 mg letsatsi le leng le le leng e nkiloe ka molomo e sireletsehile ho fihlela likhoeli tse 6. Litekanyetso tse phahameng tsa 1200-1500 mg letsatsi le leng le le leng li nkuoe ka molomo li bolokehile ho fihlela libeke tse 4. Sehlahisoa sa ngaka sa cannabidiol (Epidiolex) se lumelloa hore se nooe ka molomo ka litekanyetso tse ka bang 25 mg / kg ka letsatsi. Li-spray tsa Cannabidiol tse sebelisitsoeng tlasa leleme li sebelisitsoe ka tekanyetso ea 2.5 mg ho fihlela libeke tse 2. Motho a ka eketsa oli ea CBD lijong le lino ho koahela tatso. Empa bakeng sa ba batlang ho thusa ka lengole le boreleli kapa mokokotlo o thata, ho ka khethoa tranelate.

 

Cannabidiol (CBDRua molemo

Cannabidiol (CBD ka bokhutšoanyane) ke kannete e ka bang teng cannabinoid e tsoang semeleng sa cannabis. Ke e 'ngoe ea li-cannabinoids tse fetang lekholo tse fumanoeng limela tsa hemp. Leha ho le joalo, ho fapana le semela se felletseng sa li-cannabis, CBD ha e na cakir e ikarabellang bakeng sa maikutlo a majoe / a phahameng ao lithethefatsi tsa boithabiso li fanang ka tsona. E ntšitsoe lipalesa le li-buds tsa semela sa hemp, CBD e hatelloa ka har'a oli mme e ntse e tsebahala ho phekola, esita le ho thibela, mefuta e mengata ea litaba tsa bophelo bo botle libakeng tseo matekoane a meriana a seng a ngolisitsoe ka molao. Oli ea CBD e matla ebile e tlhaho ho feta lithethefatsi tse ngata tse seng li-steroidal tse khahlanong le ho ruruha (NSAIDs). Lintho ka bobeli li ka ntšoa le ho ntlafatsoa bakeng sa ts'ebeliso ea distillation ea tsela e khuts'oane. Basebelisi ba ka fumana melemo e latelang ea bophelo bo botle:

Ho se robale le ho tšoenyeha

Mathata a Neurodegenerative

Laola ho oa

Mathata a amanang le bophelo bo botle ba kelello

* Boleng ba Boroko

* Tsamaiso ea bohloko

Bophelo ba Lesapo

* Bokhoba le ho Itšepa

* Ho hola butle ha lefu la Alzheimer's

* E alafa mafu a ho ruruha mala

* Thuso e fana ka phomolo ho batho ba nang le multiple sclerosis

 

Cannabidiol (CBDLitla-morao

Litla-morao tsa Cannabidiol (CBD) li kenyelletsa ho otsela, mathata a ka mpeng, molomo o omileng, ho fokotsa takatso ea lijo, ho nyekeloa ke pelo le ho sebelisana le meriana e meng.

Cannabidiol (CBDKopo

Cannabidiol e sebelisoa haholo bakeng sa lefu la ho tšoaroa ke lefu la sethoathoa (lefu la sethoathoa), Cannabinoid li sebelisoa ka mokhoa oa cytochrome P450 enzyme mme li thibela boholo ba li-enzyme tsa CYP3A4 le CYP2D6. THC le CBD li fumanoe li thibela li-enzyme tsa CYP1A1, 1A2 le 1B1 nakong ea lithuto tsa in vitro. Ho phaella moo CBD ke inhibitor e matla ea CYP2C1P le CYP3A4. Ha liteko tse ngata tsa bongaka li ntse li tsoela pele, CBD e bonts'a bokhoni bo makatsang ba ho ba kalafo e tlatselletsang maemong a fapaneng a methapo. E fumanoe e na le litlamorao tsa antioxidant, anti-inflammatory, le neuroprotective. E bontšitse ts'episo kalafong ea mathata a methapo a kang ho tšoenyeha, bohloko bo sa foleng, trigeminal neuralgia, lefu la Crohn, lefu la Parkinson hammoho le mafu a kelello.

Cannabidiol Summary

Cannabidiol ke li-cannabinoid tse fumanehang ka molomo tse sebelisetsoang ho phekola bakuli ba nang le lefu la sethoathoa ka lebaka la Lennox-Gastaut kapa Dravet syndrome. Cannabidiol e amahanngoa le ho phahama ha li-enzyme tsa serum khafetsa nakong ea kalafo haholoholo ka tekanyetso e phahameng empa ha e so ka e hokahanngoa le linyeoe tsa ho lemala ha sebete ho bonahalang le le jaundice.

 

Reference

1.Britch SC, Babalonis S, Walsh SL Cannabidiol: pharmacology le liphofu tsa kalafo. Psychopharmacology (Berl). 2021 Pherekhong; 238 (1): 9-28. doi: 10.1007 / s00213-020-05712-8. PMID: 33221931.

2. Samanta D. Cannabidiol: Tlhatlhobo ea Ts'ebetso ea Tleliniki le Polokeho ho sethoathoa. Pediatr Neurol. 2019 Pherekhong; 96: 24-29. doi: 10.1016 / j.pediatrneurol. PMID: 31053391.

3. Huestis MA, Solimini R, Pichini S, Pacifici R, Carlier J, Busardò FP.Cannabidiol Liphello Tse Ntle le Chefo. Curr Neuropharmacol. 2019; 17 (10): 974-989. doi: 10.2174 / 1570159X17666190603171901. PMID: 31161980.

4. Pisanti S, Malfitano AM jj Cannabidiol: Boemo ba botaki le liphephetso tse ncha bakeng sa ts'ebeliso ea kalafo. Meriana Ther. Kajeno Jul; 2017: 175-133. doi: 150 / j.pharmthera.PMID: 10.1016.

5. Burstein S. Cannabidiol (CBD) le lipapiso tsa eona: tlhahlobo ea litlamorao tsa tsona ho ruruheng. Bioorg Med Chem. 2015 La 1; 23 (7): 1377-85. doi: 10.1016 / j.bmc.2015.01.059. PMID: 25703248.

 

Lingoloa tse Tloaelehileng