Tadalafil

CMOAPI e na le mefuta e felletseng ea thepa e tala ea Tadalafil, mme e na le tsamaiso eohle ea taolo ea boleng.Also e fetisitse GMP le setifikeiti sa DMF.

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Tadalafil ke eng

Tadalafil ke sethethefatsi se tlamang se sebelisoang ho phekola ho se sebetse ha erectile (ED) le matšoao a prostate e atolositsoeng ho banna. E boetse e bonts'oa ho alafa pulmonary arterial hypertension (PAH).
Tadalafil (Nomoro ea CAS: 171596-29-5) e fumaneha ka sebopeho sa letlapa la molomo kapa tadalafil phofo mme e rekisoa haholo tlasa lebitso la lebitso la Cialis (bakeng sa ho se sebetse ha erectile kapa ho holisoa ha senya ea senya) kapa Adcirca (bakeng sa khatello ea methapo ea methapo ea methapo). Tadalafil e boetse e fumaneha ka sebopeho sa eona sa generic se kanna sa ba le matla ohle joaloka sebopeho sa mantlha


Tadalafil e sebetsa joang?

Tadalafil ke e 'ngoe ea li-inhibitors tsa phosphodiesterase tsa mofuta oa 5 (PDE5). Ha lihlopha tsena tsa lithethefatsi li thibela PDE5 le tsona li ntlafatsa tšebetso ea erectile.
Nakong ea tsoho ea thobalano, ho tsoaloa ho etsahala ha ho na le phallo e lekaneng ea mali methapong ea penile e hlahisang methapo e phutholohileng le mesifa e boreleli ea corpus cavernosum. Karabo ena e lekantsoe ke tlhahiso ea nitric oxide (NO) liseleng tsa endothelial le litsing tsa methapo. Ho lokolloa ha NO ho matlafatsa tšebetso ea cyclic guanosine monophosphate (e tsejoang haholo ka hore ke cyclic GMP kapa cGMP) liseleng tse boreleli tsa mesifa. GMP ea cyclic e thusa ho khatholla mesifa e boreleli mme e eketsa phallo ea mali ho corpus cavernosum.
Tadalafil e thibela mofuta oa 5 oa phosphodiesterase (PDE5) ka ho eketsa palo ea cGMP. Ke habohlokoa ho hlokomela hore motho o tlameha ho ba le tšusumetso ea thobalano ho qala tokollo ea tlhaho ea nitric oxide. Lebaka ke hore litlamorao tsa Tadalafil li ke ke tsa etsahala ntle le ts'usumetso ea thobalano.
Tadalafil e ka fokotsa matšoao a litšoelesa tse atolositsoeng tsa "prostate" ho kenyelletsa ho rota ka potlako / khafetsa, bothata ba ho ntša metsi le ho se ts'oarehe ha moroto. E fihlella sena ka ho phomotsa mesifa ea senya le senya.
Ka khatello ea mali ea pulmonary, tadalafil e thusa ho khatholla methapo ea mali ka sefubeng. Sena le sona se thusa ho eketsa phepelo ea mali matšoafong hape ho fokotsa mosebetsi oa pelo.


Batlatsi ba Tadalafil

Nakong ea ho hlahisa tadalafil (CAS 151596-29-5), ho buloa baemeli ba bang. Likhamphani tse ling li tla sebelisa li-intermediate tsa tadalafil ho hlahisa tadalafil.

Tlhahlobo 171596-29-5

Tadalafil (CAS 171596-29-5) ke setlhare se matla le se sebetsang sa kalafo bakeng sa ho phekola ho se sebetse ha erectile le ho atolosoa ha prostatic ho banna le methapo ea methapo khatello ea mali.

Tlhahlobo 171489-59-1

Cas 171489-59-1 eo hape e bitsoang Chloropretadalafil e bohareng ba tlhahiso ea Tadalafil e sebelisitsoeng ho phekola ho se sebetse ha erectile. CAS 171489-59-1 e na le foromo ea molek'hule C22H19ClN2O5 e nang le molek'hule ea 426.85 g / mol. E fumaneha ka sebopeho sa tiiso e tšoeu.

Tlhahlobo 171752-68-4

CAS 171752-68-4 eo molek'hule ea eona e leng C20H18N2O4.HCl le boima ba limolek'hule tsa 386.83 g / mol le eona ke tadalafil e mahareng.
Ho na le barekisi ba bangata ba li-intermediate tsa tadalafil ba fanang ka li-intermediate tsa tadalafil tse rekisoang ka theko ea tlholisano. Leha ho le joalo, ha u nahana hore tadalafil e reke ho lik'hamphani tse tšepahalang ho netefatsa hore boleng ha bo na eona.
CMOAPI ke e 'ngoe ea barekisi ba li-tadalafil ba lipakeng ba fanang ka boleng bo botle le tlholisano ea litheko tsa lihlahisoa tsa bona.


Ke mang le mokhoa oa ho sebelisa tadalafil

Tadalafil phofo e ka phekola tse latelang ho banna?

Ho se sebetse ha Erectile

Ho se sebetse ha Erectile (ED) eo hape ho thoeng ke ho hloka matla ke boemo ba banna moo ba sa khoneng ho fumana kapa ho boloka erection bakeng sa nako e lekaneng ea ho etsa thobalano. Hangata ho lebisa thahasellong ea thobalano hape ho ka baka mathata a mang a joalo ka ho emisa pele ho nako kapa ho lieha ho emisa 'me ka linako tse ling ho se khone ho fihlela mokhelo.
ED e ka bakoa ke mabaka a mangata maemo a 'mele le maikutlo joalo ka mafu a mang a kang lefu la tsoekere, lefu la pelo, le khatello ea mali, lilemo, khatello ea maikutlo kapa mathata a kamano.
Tadalafil e thusa ho phekola ED ka ho eketsa phallo ea mali ho ea botoneng. Sena le sona se thusa ho fihlela le ho boloka erection. Leha ho le joalo, tadalafil e thusa feela ka ho tsoha ha motho a se a ntse a tsosa takatso ea thobalano.

Benign prostatic hyperplasia (BPH)

E boetse e bitsoa ho atolosoa ha tšoelesa ea senya, BPH ke boemo bo tloaelehileng bo atisang ho fumanoa ho banna botsofaling ba bona. Leha ho le joalo, mabaka a mang a 'maloa a ka lebisa ho atolositsoeng ha senya ho kenyelletsa lefu la tsoekere le mathata a pelo, mokhoa oa bophelo, haholo-holo botenya le nalane ea lelapa ea BPH. Ha prostate e hola e ka lebisa maemong a ho ntša metsi.
Matšoao a amanang le tšoelesa ea "Prostate" e atolositsoeng ke, ho potlaka le khafetsa khafetsa ho ntša metsi, ho ba le bothata ba ho qala ho ntša metsi, molapo o fokolang oa moroto, kapa ho se khone ho tšolla senya ka botlalo. Matšoao a mang a BPH a ka kenyelletsa tšoaetso ea mosese (UTI), e sa khone ho ntša metsi, kapa mali ka morong.
Tadalafil phofo kapa letlapa le thusa ho khatholla mesifa ea senya le senya. Sena se thusa ho imolla matšoao a BPH.

Matšoafo a methapo ea methapo ea mali (PAH)

PAH ke boemo boo ho nang le khatello ea mali e phahameng methapong e fanang ka mali matšoafong. E fapane le khatello e phahameng ea mali e tloaelehileng. E etsahala ha methapo e tsoang pelong ho ea matšoafong e ba mosesane kapa e koetsoe.
Matšoao a tsebahalang haholo a kenyelletsa bohloko ba sefuba, mokhathala, esita le ho ruruha maotong le maqaqailaneng.
Tadalafil e ka thusa ho imolla matšoao a PAH ka ho phomotsa methapo ea mali matšoafong e eketsang phallo ea mali ka tatellano.

U ka sebelisa tadalafil joang?

Tekanyo ea tadalafil e ipapisitse le lilemo tsa hau, ts'ebeliso e reretsoeng, le mathata afe kapa afe a bongaka.
Ts'ebeliso ea Tadalafil ha e khothalletsoe bakeng sa bana ba ka tlase ho lilemo tse 18 ha le ba tsofetseng ba fetang lilemo tse 65 ba lokela ho ba hlokolosi haholo hobane 'mele ea bona e nka nako e telele ho monya lithethefatsi tsena.
Ho na le litataiso tse hlakileng tsa mokhoa oa ho sebelisa tadalafil powder empa mofuta o tloaelehileng haholo ke letlapa la tadalafil tlasa mabitso a mabitso a fapaneng.
Ho eletsoa ho nka tadalafil hang ka letsatsi le ho e nka ka nako e ts'oanang letsatsi le leng le le leng ho fumana melemo ea tadalafil.
Tekanyo ea tadalafil bakeng sa ts'ebeliso e fapaneng e ea hlalosoa;
Bakeng sa ho se sebetse hantle ha erectile, tekanyetso ea 2.5-5 mg e nkuoa letsatsi le letsatsi kapa 10 mg ha e nkuoa hanngoe ho latela tlhoko ea tlhoko.
Bakeng sa benign prostatic hyperplasia, tekanyetso ea 5 mg e nkuoang letsatsi le letsatsi ea khothaletsoa. Tadalafil e lokela ho nkuoa hang ka letsatsi.
Ha o sebetsana le maemo ana ka bobeli (ho se sebetse ha erectile le prostate e atolositsoeng) tekanyetso ea 5 mg ka letsatsi e loketse.
Ka khatello ea methapo ea methapo ea methapo, ho hlahisoa tekanyetso ea tadalafil ea 40 mg e nkuoang letsatsi le letsatsi.
Joalo ka lithethefatsi tse ling, se sebeletsang motho se kanna sa se etse se tšoanang ho se seng. Mekhoa e meng ea Tadalafil e teng. Leha ho le joalo, ntho e molemohali eo u lokelang ho e etsa ke ho bua le ngaka ea hau ka mekhoa e meng e fumanehang ea tadalafil 'me u bone hore na ke life tse u loketseng. U kanna oa eletsoa hore u nke mefuta e meng ea tadalafil haeba u na le alejiki ho tadalafil kapa ka mabaka a mang.
Ke boikarabello ba hau ho hlokomela se u sebeletsang hantle ha u ntse u re tadalafil ke khetho kapa litla-morao tsa tadalafil li felisa melemo ea tadalafil.


Ke phapang efe lipakeng tsa Tadalafil le meriana e meng ea ho se sebetse ha erectile

Cialis (Tadalafil)

Cialis ke moriana oa ngaka sehlopheng sa litlhare tse bitsoang Phosphodiesterase-5 Enzyme Inhibitors. E sebelisetsoa ho sebetsana le matšoao a ho se sebetse ha erectile. E ka sebelisoa e le mong kapa e kopantsoe hammoho le lithethefatsi tse ling.

Dapoxetine Hydrochloride

Dapoxetine hydrochloride e khetholloa e le serotonin reuptake inhibitors (SSRIs) e sebetsang ka potlako.
Dapoxetine hydrochloride ke sethethefatsi se ngolisitsoeng se sebelisetsoang ho phekola ho tsoa peo pele ho nako. Ho ejaculation pele ho nako ke boemo bo tloaelehileng haholo ho banna bo amanang le ho se khone ho liehisa ho khaotsa. Ena ke letšoao le leng la ho se sebetse ha erectile ho banna.
Le ha tadalafil le dapoxetine hydrochloride li sebelisoa ho sebetsana le matšoao a ho se sebetse ha erectile, e 'ngoe ea tadalafil ke phosphodiesterase inhibitor ha e' ngoe, dapoxetine, ke serotonin reuptake inhibitor e khethiloeng.

Vardenafil Hydrochloride

Vardenafil ke moriana sehlopheng sa litlhare tse bitsoang phosphodiesterase (PDE) inhibitors. E sebelisetsoa ho sebetsana le ho se sebetse ha banna ka erectile. Ha monna a tsosoa ka thobalano, vardenafil e eketsa phallo ea mali ho ea botoneng e netefatsang hore o fumana tsoho.
Vardenafil e rekisoang tlasa lebitso la lebitso la Levitra e khetha haholo ho feta sildenafil le tadalafil (Cialis) ho PDE5. Sena se bolela feela hore ho hlokahala tekanyo e tlase ea vardenafil ka litla-morao tse fokolang tse ka bang teng.
Phapang e 'ngoe e tsebahalang ke halofo ea bophelo moo vardenafil (Levitra) e nang le halofo ea lihora tsa 4-6 ha tadalafil (Cialis) e na le halofo ea lihora tsa 17.5. Sena se bolela hore Tadalafil (Cialis) e sebetsa nako e telele ho feta vardenafil.

Avanafil

Avanafil ke moriana sehlopheng sa li-phosphodiesterase inhibitors. E boetse e sebelisoa ho sebetsana le ho se sebetse ha erectile ka ho ntlafatsa phallo ea mali sebakeng sa penile.
Le ha avanafil le tadalafil e le phosphodiesterase inhibitors, avanafil ke eona e ncha ka ho fetesisa ebile e na le halofo ea bophelo e khuts'oane ea lihora tse ka bang 5 ho feta tadalafil e nang le halofo ea lihora tse 17.5
Qetellong, tadalafil e ntle haholo ka lebaka la halofo ea bophelo ba eona. Motho a ka noa meriana ka litla-morao tse 'maloa tse ka bang teng.


Phello ea lehlakoreng la Tadalafil le melemo

Melemo ea Tadalafil

Ba bangata ba nahanang ho sebelisa tadalafil powder ba e reka ka lebaka la melemo ea eona ea mantlha ea tadalafil;

Ho sebetsana le ho se sebetse ha erectile

Penile erection ke ts'ebetso ea bohlokoa bakeng sa thobalano. Ho se sebetse ha Erectile ho etsahala ha monna a sa khone ho fumana le ho boloka erection. Sena se baka mathata a mangata a joalo ka khatello ea maikutlo, boitlhompho bo tlase, esita le mathata a kamano.
Ts'ebetso e fihlella ha phallo ea mali e lekana botoneng. Tadalafil e thusa ho imolla matšoao a ho se sebetse hantle ka ho eketsa phallo ea mali botoneng.

Ho phekola matšoao a benign prostatic hyperplasia

Benign Prostatic hyperplasia e boetse e bitsoa tšoelesa ea prostate e atolositsoeng. Boemo bona bo hlahang ka tlhaho ka lilemo. Ha tšoelesa ea senya e hola, e pepeta mosese. Matšoao a mang a amanang le prostate e atolositsoeng ke; ho rota kapele le khafetsa, ho le thata ho qala ho ntša metsi, ho ntša metsi hampe har'a ba bang.
Tadalafil e thusa banna ba nang le lefu la benign prostatic hyperplasia ka ho imolla matšoao ana. Tadalafil phofo e thusa ho phutholla tšoelesa ea senya hammoho le senya kahoo e fokotsa matšoao a amanang le senya le khatello ea senya.

E ka sebetsana le ho se sebetse hantle ha erectile le benign prostatic hyperplasia

Tadalafil e ka boela ea thusa banna ba nang le bothata ba ho se sebetse ha erectile le ho holisa tšoelesa ea senya ka nako e le 'ngoe.
Ha o sebelisa tadalafil ka litekanyo tse nepahetseng le kamoo u khothalelitsoeng u kotula melemo e boletsoeng. Kaha ke matlafatsa phallo ea mali sebakeng sa penile le libakeng tse ling, ke tsela e nepahetseng ea ho sebetsana le maemo ana.

E ka sebelisoa hape ho phekola matšoao a khatello ea mali ea methapo

Pulmonary arterial hypertension (PAH) ha e le hantle e bolela hore ho na le khatello e phahameng ea mali methapong e ntšang mali ho tsoa pelong ho ea matšoafong. Leha ho le joalo e fapane le khatello ea mali e tloaelehileng.
PAH e hlaha ha methapo e fepelang mali matšoafong e ba mosesane kapa e koetsoe e isang pelo ho qobelloa ho pompa mali ka sekhahla se phahameng. Lebelo lena le potlakileng le le qobelloang la pelo le baka khatello e matla methapong ea methapo.
Tadalafil phofo ea makatsa ka ho phomotsa methapo ea mali. Phomolo ena e lumella phallo e boreleli ea mali ka hona e eketsa sekhahla sa phallo. Sena se thusa pelo ho pompa mali a boreleli ka hona ho imolla khatello e neng e tla bokellana

E ntlafatsa bokhoni ba hau ba ho ikoetlisa

Nakong ea boikoetliso phallo ea mali e bohlokoa ho lumella motho ho fumana oksijene e lekaneng hape ho hlahisa matla a lekaneng a hlokahalang.
Tadalafil e ka matlafatsa ts'ebetso ea hau ea boikoetliso ka ho phomotsa methapo ea hau ea mali le ho eketsa phallo ea mali.

Litlamorao tsa Tadalafil

Litla-morao tse tloaelehileng tsa tadalafil li kenyelletsa;

  • Hlooho e bohloko,
  • Ho nyekeloa,
  • ho futhumatsa (mofuthu, bofubelu, kapa ho utloa bohloko),
  • ho halefa mala,
  • nko e khutsitseng kapa e mathang, le
  • bohloko ba mesifa, bohloko ba mokokotlo le bohloko matsohong kapa maotong.

Tadalafil le eona e ka lebisa litlamorao tse mpe haholo. U eletsoa hore u batle thuso ea bongaka haeba u ba le litlamorao tse latelang tsa tadalafil;

  • matšoao a mang a lefu la pelo a kenyeletsang bohloko ba sefuba, bohloko bo namelang mohlahareng kapa lehetleng, ho nyekeloa ke pelo le ho fufuleloa.
  • liphetoho tsa pono ho kenyeletsoa pono e sa bonahaleng kapa tahlehelo ea pono ka tšohanyetso.
  • ho futhumatsa (mofuthu, bofubelu, kapa ho utloa bohloko),
  • Ho senyeha ha kutlo ho
  • ho lla litsebeng tsa hao le ho lahleheloa ke kutlo
  • Erection e bohloko kapa e nka nako e telele ho feta lihora tsa 4 kaha sena se ka senya botona ba hau.
  • Ho otla
  • Ho otlolla pelo ho sa tloaelehang
  • Ho tepella, ho tsekela le,
  • Mokhathala o sa tloaelehang.

Likamano tsa lithethefatsi tsa Tadalafil

Ho tlalehiloe litšebelisano tse 'maloa tsa tadalafil le lithethefatsi tse ling. Likamano tsa lithethefatsi hangata li fetola ts'ebetso ea meriana 'me li ka sitisa lithethefatsi ho sebetsa hantle.
Ka hona ho eletsoa haholo hore u buisane ka meriana ea hau pele u sebelisa tadalafil. Likamano tse ling tsa tadalafil li ka ba bonolo ebile tse ling li mpe.
Ka tlase ke litšebelisano tsa tadalafil;

Nitrate

Li boetse li bitsoa lithethefatsi tsa Anguina. Ha li-nitrate li nkuoa hammoho le tadalafil, e ka baka hore khatello ea mali e theohele maemong a tlase haholo. Boemo bo tlase ba khatello ea mali bo amahanngoa le matšoao a kang ho tsekela kapa esita le ho akheha.
Tse ling tsa lithethefatsi tsena tsa bohloko li kenyelletsa; butyl nitrite, amyl nitrite, isosorbide dinitrate, nitroglycerin, le isosorbide mononitrate.

Alpha-blockers

Tsena ke lithethefatsi tse sebelisoang ho lokisa khatello e phahameng ea mali. Li boetse li sebelisoa kalafong ea senya. Li-tadalafil le alpha-blockers ka bobeli ke li-vasodilator tse nang le khatello ea khatello ea mali. Ha e sebelisoa hammoho, e ka baka lerotholi le matla / le leholo la khatello ea mali. Sena se etsa hore motho a hloloe hlooho hape a ka akheha.
Tse ling tsa lithethefatsi tsa alpha-blockers li kenyelletsa; terazosin, tamsulosin, alfuzosin le prazosin.

Meriana e meng ea HIV

Meriana ena ke li-protease inhibitors mme ka hona e ka eketsa boemo ba tadalafil maling. Keketseho ena e baka khatello e tlase ea mali. E ka baka leeme ho banna ho bolelang hore ba fumana erection e telele eo hangata e leng bohloko.
Tse ling tsa lithethefatsi tsena ke ritonavir le lopinavir.

Likokoana-hloko

Likamano tsa Tadalafil le lithibela-mafu li tlalehiloe. Ha li nkuoa hammoho le tadalafil, lithibela-mafu li ka eketsa boemo ba tadalafil maling e lebisang khatellong ea mali. O ka fella ka ho tsekela, ho akheha, esita le mathata a mang a pono. E kanna ea baka leeme ho banna.
Tse ling tsa lithethefatsi tsena ke erythromycin, telithromycin le clarithromycin.
Leha ho le joalo, lithibela-mafu tse ling li ka theola maemo a tadalafil maling. Likamano tsena tsa tadalafil ha li sebetse hantle. Lithethefatsi tsena li kenyelletsa; rifampin.

Lithethefatsi tse thibelang mafu

Meriana e meng ea antifungal ea molomo e kenyelletsa ketoconazole le itraconazole e sebelisana le tadalafil.
Lithethefatsi tsena li ka phahamisa boemo ba tadalafil e lebisang ho botsoa le ho akheha le tsona li ka etsahala.

Lithethefatsi tse ling tsa khatello ea kelello ea methapo

Tadalafil le lithethefatsi tse ling tsa khatello ea mali e phahameng li na le litlamorao tse tlase tsa khatello ea mali. Ha e sebelisoa hammoho e ka lebisa maemong a tlase a khatello ea mali. Sena se baka matšoao a amanang le khatello e tlase ea mali a kang ho ba le botsoa le ho akheha.
Lithethefatsi li kenyelletsa riociguat.

Li-antacid

Lithethefatsi tsena li sebelisetsoa ho theola asiti ea ka mpeng. Ha e sebelisoa hammoho le tadalafil, e kanna ea sitisa ho monya tadalafil 'meleng. Li kenyelletsa magnesium hydroxide kapa aluminium hydroxide.

Meriana ea lefu la sethoathoa

Tsena li boetse li bitsoa litlhare tse khahlano le bosholu. Ha o sebelisa lithethefatsi tse loantšang ho ts'oaroa le tadalafil, li ka fokotsa monya oa tadalafil. Sena se bolela hore tadalafil e ke ke ea khona ho sebetsa hantle. Lithethefatsi tsena tsa lefu la sethoathoa li kenyelletsa phenytoin, phenobarbital le carbamazepine.


O ka reka Tadalafil kae?

U ka etsa hore Tadalafil e reke mabenkeleng a marang-rang. Phofo e fumaneha ka bongata ho bafuputsi le bahlahlobisisi. Etsa bonnete ba hore o sheba li-tadalafil tse fanang ka phofo ha o nahana ho nka tadalafil e reke ho barekisi ba tšepahalang.
Ikopanye le ngaka ea hau pele u nka tadalafil ka lebaka la litlamorao tsa tadalafil hammoho le ts'ebelisano ea tadalafil le lithethefatsi tse ling.
Haeba o batla Tadalafil kapa li-intermediates tsa eona, o lokela ho sheba le CMOAPI bakeng sa phepelo e nepahetseng ea lihlahisoa tse hloekileng. Metsoako ea rona e fumane netefatso ea boleng.


References
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  3. "Cialis tadalafil PI". Tsamaiso ea Thepa ea Thepa ea Phekolo. E khutlisitsoe ka 2020-08-19.
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